Microgravity bioreactor
Classification:
- Description
- Characteristic
- Configuration
- Technical Parameter
- Control System
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Horizontal rotating bioreactor (microgravity bioreactor) that can be sterilized online.
BR Microgravity Reactor is a rotating reactor that can simulate microgravity environment. It consists of a rotating container, a motor, a frame and a control system. The outer wall of the reactor rotating container can be stationary or rotate with the inner shaft. It is widely used in biomedicine, chemical industry, electronics and other fields.
Technical background:
Bioreactors are devices that enable large-scale cell culture. From a development perspective, the major changes in bioreactors in the 1940s came from the fact that people transplanted the knowledge of chemical reactors to the fermentation industry and developed mechanically stirred bioreactors, making large-scale pure strain culture possible. The genetic engineering and cell engineering technologies developed in the 1970s expanded fermentation engineering from natural microorganisms to the cultivation of genetically engineered bacteria, animals and plant cells. At the same time, new requirements were put forward for bioreactors, forming the structural framework of "four transmissions (momentum, mass, heat, information) and one reaction (bioreaction kinetics)" in bioreaction engineering. In recent decades, due to the development of bioengineering and tissue engineering, the level of corresponding bioreactors has also been continuously improved, and bioreactors used for tissue engineering culture have become closer and closer to the culture conditions of the biological environment.
Simulated microgravity culture is an emerging culture technology that can be used in many fields such as tissue engineering and cell culture. Horizontal rotary bioreactors can simulate microgravity environments and have the advantages of sufficient oxygen and nutrient exchange, three-dimensional structure, extremely low shear force and unique fluid mechanics. This improves the culture conditions of in vitro cells, allowing mammalian cells that can only grow in two-dimensional adherent growth under normal conditions to show three-dimensional proliferation and cell differentiation. Such differentiated cell clusters can further form functional tissue blocks. Horizontal rotary bioreactors represented by the rotary cell culture system (RCCS) invented by NASA are widely used in the field of life sciences, but they are sterilized by either autoclave steam sterilization or ethanol immersion, which is complicated and time-consuming to operate and is prone to incomplete sterilization, especially in large-scale production.
Features:
Birui's online sterilization horizontal rotating bioreactor has a reasonable structure and ingenious design. It can not only simulate the microgravity environment but also achieve online sterilization. It is a new horizontal rotating bioreactor system with unlimited volume and can carry out large-scale cell or tissue culture.
appendix:
RCCS-1 Rotary Cell Tissue Batch Culture System User Manual
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* The horizontally rotating reactor can simulate a microgravity environment, allowing the reactants inside to escape the influence of gravity and float inside the container without colliding with the outer wall or inner axis.
* Multiple functional holes can be opened on the container wall according to user needs for exhaust, sampling, feeding, etc.
* The speed is adjustable, the control range is 0-300rpm, and the control accuracy is ±1rpm.
* The container is made of high temperature resistant material and can be sterilized repeatedly or used once.
* Small size, easy to assemble and disassemble.
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