Horizontal rotating bioreactor (microgravity bioreactor) that can be sterilized online. Technical background: Bioreactor is a device that enables large-scale cell culture. From the perspective of development, the major changes in bioreactors in the 1940s came from the fact that people transplanted the knowledge of chemical reactors to the fermentation industry and developed mechanical stirring bioreactors, which made large-scale pure strain culture possible. The genetic engineering and cell engineering technologies developed in the 1970s expanded fermentation engineering from natural microorganisms to the cultivation of genetically engineered bacteria, animal and plant cells.
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